Objective To explore the feasibility of case management combining mobile medical application(mHealth APP) for patients with type 2 diabetes(T2DM) and its impact on self-management behavior and empowerment abilities. Methods A total of 300 inpatients with type 2 diabetes in a tertiary hospital in Jiangsu were enrolled from April 2017 to March 2018,and they were randomly divided into 2 groups:case management control group(n=150) and case management combining mHealth APP intervention group(n=150). Both groups received case management during hospitalization. After discharge,the patients in the control group continued to receive case management,while the intervention group was managed by mHealth APP on the basis of the control group. The biochemical indexes were monitored and the SDSCA scale and DES-SF scale were completed before the intervention and 12 months after the intervention. Results Before the intervention,there was no statistically significant difference between the 2 groups. The total scores and the score of each dimension(Diet,Exercise,Blood Glucose Monitoring,Medication and Foot Care)in SDSCA,and the DES-SF score were higher than those before the intervention(P<0.01). 12 months after the intervention,there were no significant difference in the total score and each dimension score of self-management behavior between the 2 groups(P>0.05). But we found that the total time of nursing management and specialist nursing outpatient service in one year was significantly less than that of the control group(P<0.01),and the improvement of the total score and items 4,8 of the DES-SF scale in the intervention group was significant than that in the control group(P<0.05) after one-year intervention. In the intervention group,HbA1c,HOMA-IR and TC were significantly reduced after 12 months of intervention(P<0.01),and self-management behaviors and empowerment ability were significantly improved after 12 months of intervention(P<0.01). Conclusion The case management combining mHealth APP can stimulate the inherent potential of self-care of patients with type 2 diabetes. It can improve various metabolic indicators and self-management capabilities while saving time and human resources effectively.